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New UCL Research - Is Your Probiotic Dead or Alive?

Thursday 25 September, 2014

60% of UK households regularly purchase probiotics. As consumer interest in probiotics has grown, so has the number and variety of products that claim to provide a beneficial effect on the GI tract - the market is now flooded with products claiming to contain 'beneficial bacteria' that helps ease digestive problems such as IBS.

Probiotic marketing campaigns often include claimed research to support them, but many manufacturers have avoided comparisons between brands using realistic tests. Now scientists at University College London (UCL) have independently conducted one of the first studies comparing some of the most popular probiotic brands available in the UK, to test which products are likely to actually survive and thrive in the gut environment. The study used representative in-vitro test systems that allow understanding of the various factors that must be controlled to give the greatest chance of delivery of live, healthy bacteria to the lower gut.

A total of eight commercially available probiotic preparations were selected by UCL to undergo these tests:

Yakult
Actimel
Align
Biobalance
Bio-kult
Probio7
Symprove
VSL#3

In the real world, to be successful a probiotic product needs to successfully beat three challenge tests-

1. Arrive safely in the gut in a live state - Were the claimed number of bacteria recoverable?

Probiotics are typically available as capsules or liquid formulations. The UCL study results indicate that at the point of consumption, liquid probiotic products contain close to or in excess of their claimed content. However, for freeze-dried products, the viable content was generally lower than the stated claim and in some cases, strikingly lower. Tablets and capsule probiotics contain multiple strains of freeze-dried bacteria, which must rehydrate to recover viability; causing many of the bacteria to be lost as they attempt to recover to an active state. Only dairy-based (Actimel, Yakult) or water-based probiotics (Symprove) delivered 100% or more than the claimed content.

2. Survive stomach acids - Do the bacteria survive exposure to gastric juices?

The initial acid shock after only 5 minutes was dramatic on almost all products, with some showing almost complete collapse. Given that most products, when used as stated on the label, will take between 30 to 120 minutes to pass through the stomach, it seems likely that very few bacteria will actually make it through alive to the small intestine. Only two products (Symprove, VSL#3) survived stomach transit time (120 minutes), with one of these continuing to decline (VSL#3). Only one product seems stable (Symprove).

3. Thrive in the target area of the gut - Are the bacteria able to grow after exposure to gastric juices?

A probiotic product must be able to grow quickly, to establish a strong colony before travelling too far along the gut and being ejected from the system. After only a 30 minute exposure to gastric acid, the products showed very different abilities to grow. Only three products showed signs of strong growth within 10 hours (Symprove, Actimel, VSL#3). Others showed very slow, or even no growth.

To conclude, only one product met all three challenges (Symprove) – with several popular products failing all three challenges. Many UK consumers are wasting millions on bacteria that simply die in the stomach.

Case Study: Lucinda Barton, from Sussex - "I've wasted hundred of pounds on products for my IBS"

Ends

Press Contact:

Sarah West

e: sarah@spinkhealth.com

t: 01444 811099



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